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Defination

Methamphetamine is a powerful stimulant that activates certain systems in the brain.It is closely related chemically to amphetamine but the central nervous system effects of methamphetamine are greater.Both drugs have some medical uses primarily in the treatment of obesity but their therapeutic use is limited.The central nervous system actions that result from taking even small amounts of methamphetamine include increased wakefulness and increased physical your activity.Also decreased appetite,increased respiration,hypethermia and euphoria.Other CNS effects include irritability,insomnia,confusion,tremors,convulsions,anxiety, paranoia and aggressiveness.The result of Hyperthermia and convulsions is death.Methamphetamine enters the brain and triggers a cascading release of dopamine,serotonin and norepinephrine.It is highly active in the mesolimbic reward pathways of the brain inducing intense euphoria with risks for addiction.To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor with high concentrations serving as a monoamine oxidase inhibitor.Many users may become hypersexual or obsessed with a task thought or activity.Withdrawal is characterized by excessive sleeping,eating and major depression often accompanied craving. Methamphetamine users may take sedatives such as benzodiazepines as a means of easing their "come down"anxiety or enable them to sleep.